What’s the real effect of a nutrient on your health?Bioactivity

To assess supplement’s bioactivity (and find out whether and how it influences main biological markers) it is necessary to define pharmacodynamics profiles. The research, carried out in compliance with Good Clinical Practice (GCP) principles, has proven superior efficacy of Carocelle® products in comparison to competitors in terms of:

  • reduction of inflammatory oxidative damage
  • reduction of LDL oxidation
  • blood and tissues oxygenation.

The influence of Carocelle® final formulas on biomarkers, not just single ingredients, has been tested. The same way as medications are:

    • 42% reduction of inflammatory oxidative damage
    Inflammatory Oxidative Damage: IOD in MDA µm [% change vs. baseline; 4 week clinical trial] [double-blind, randomized; Lycotec Ltd., Cambridge, UK]
    Inflammatory Oxidative Damage: IOD in MDA µM

    * Concentration of the end products of lipid peroxidation such as malondialdehyde (MDA) measured by colorimetric methods.

    • 58% reduction of ox-LDL level
    Inflammatory Oxydative Damage Reduction: LDL-Px in % change vs. baseline [% change vs. baseline; 4 week clinical trial] [double-blind, randomized; Lycotec Ltd., Cambridge, UK]
    Inflammatory Oxydative Damage Reduction: LDL-Px in % change vs. baseline

    * LDL-Px are specific antibodies which have the unique feature of being capable of causing oxidation of lipids in low density lipoprotein (LDL) particles and atherogenic changes. LDL-Px activity was measured comparing sample active antibodies with the one with inhibited LDL-Px activity (not atherogenic). The measurements were conducted spectrophotometrically.

    • 82% improved plasma oxygen saturation
    Plasma Oxygen Transport in U/ml [% change vs. baseline; 4 week clinical trial] [double-blind, randomized; Lycotec Ltd., Cambridge, UK]
    Plasma Oxygen Transport in U/ml

    * Lipoprotein fractions were obtained from plasma by centrifugation to prepare micellar solutions. A mixture of NADH and PMS was used to produce of superoxides which were monitored spectrophotometrically by a colorimetric reaction of NBT to monoformazan reduction.

    • superior % reduction of inflammatory oxidative damage
    Inflammatory Oxydative Damage: LDL-Px in Elisa x103 [% change vs. baseline; 4 week clinical trial] [Lycotec Ltd., Cambridge, UK]
    Inflammatory Oxydative Damage: LDL-Px in Elisa x10³

    * Concentration of the end products of lipid peroxidsation such as malondialdehyde (MDA) measured by colorimetric methods.

    Inflammatory Oxidative Damage in MDA (µM) [% change vs. baseline; 4 week clinical trial] [double-blind, randomized, placebo-controlled trial; Lycotec Ltd., Cambridge, UK]
    Inflammatory Oxidative Damage in MDA (µM)

    * Concentration of the end products of lipid peroxidation such as malondialdehyde (MDA) measured by colorimetric methods.

    • 39% improved tissue oxygen saturation
    Tissue oxygen saturation [%O2/min.] [% change vs. baseline; 4-week supplementation] [Lycotec Ltd., Cambridge, UK]
    Inflammatory Oxidative Damage in MDA (µM)

    * The measurements were made before and after occlusion of the brachial artery (NIRS). The AUC, of the recorded signal for the settling time in the post occlusion period was calculated in % O2/minute.

    • 34% improved plasma oxygen transport
    Plasma oxygen transport [U/ml] [% change vs. baseline; 4 week of supplementation] [Lycotec Ltd., Cambridge, UK]
    Inflammatory Oxidative Damage in MDA (µM)

    * Lipoprotein fractions were obtained from plasma by centrifugation to prepare micellar solutions. A mixture of NADH and PMS was used to produce superoxides which were monitored spetrophotometrically by a colorimetric creaction of NBT to monoformazan reduction.